2/21/2024 0 Comments Hospital santa matilde madridThe Cohort of the Spanish HIV/AIDS Research Network (CoRIS) is an open, multicentre, prospective cohort of HIV-positive adults, naive to ART at study entry, who were seen for the first time in a specialist HIV clinic from 1 January 2004 in any of the 47 centres from 14 of 17 Autonomous Regions in Spain, and followed up until 30 November 2021, the administrative censoring date for these analyses.īriefly, CoRIS collects a minimum dataset as provided for in the cohort protocol, which includes baseline and follow-up sociodemographic, immunological and clinical data including data on antiretroviral medications with start and stop dates and reasons for drug discontinuation. Specifically, among treatment-naive patients, we aimed to compare the effectiveness and tolerability of dolutegravir/lamivudine with the most frequently prescribed first-line three-drug regimens (3DRs), and to assess its effectiveness among specific subgroups such as those with low CD4 cell counts or high VLs. The aim of this study was to assess the effectiveness and tolerability of dolutegravir/lamivudine among treatment-naive and virologically suppressed treatment-experienced individuals in a large multicentre cohort in Spain. As an example, only two cohorts have studied dolutegravir/lamivudine as first-line therapy involving more than 100 subjects, and neither of them compared its effectiveness with other treatments. Most importantly, among treatment-naive patients, most of these cohorts are only descriptive, single-arm studies that do not compare the effectiveness of dolutegravir/lamivudine with other drug regimens. Most of them involve a limited number of subjects and/or a single centre: this limits the power of the study to compare its effectiveness with other ARTs and the analysis of certain subgroups of interest, such as those with low CD4 cell counts or high plasma viral loads (VLs). 7–10 However, these studies have several shortcomings, especially regarding treatment-naive patients. Several cohort studies have evaluated the use of dolutegravir/lamivudine in clinical practice worldwide, confirming the results of the previous clinical trials. Therefore, it is important that the information from clinical trials of ART is complemented by real-life studies. 3, 4Ĭlinical trials usually involve selected subjects that are not fully representative of the general population and take place in settings with frequent and standardized follow-up procedures that might not reflect day-to-day clinical practice. DT as a combination of dolutegravir (DTG) and lamivudine (3TC) has shown high efficacy and good safety and tolerability in clinical trials, both in treatment-naive 1, 2 and treatment-experienced patients who are virologically suppressed. During the first 48 weeks after dolutegravir/lamivudine initiation, 1.0% of treatment-naive and 1.5% of treatment-experienced subjects discontinued dolutegravir/lamivudine due to an adverse event.Īlthough for many years the use of three antiretroviral drugs has been the standard treatment of HIV infection, two-drug regimens (dual therapy, DT) have been increasingly used with the aim of simplifying the treatment and minimizing toxicity. The probability of achieving VS with dolutegravir/lamivudine was not significantly different compared with any other regimen at 24 or 48 weeks, with the exception of a lower chance of achieving VS at 24 weeks for DRV/COBI/FTC/TAF (adjusted OR: 0.47 95% CI: 0.30–0.74) compared with dolutegravir/lamivudine.įor the analysis of treatment-experienced virally suppressed subjects we included 1456 individuals who switched to dolutegravir/lamivudine, among whom 97.4% and 95.5% maintained VS at 24 and 48 weeks, respectively. At 24 and 48 weeks after starting dolutegravir/lamivudine, 91.4% and 93.8% of the subjects, respectively, achieved VS. We included 2160 treatment-naive subjects, among whom 401 (18.6%) started with dolutegravir/lamivudine.
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We’ll get into that a bitīecause both AI Wars provides this unique premise, it’s easy Or two from the massively-successful AI War 1 (hereafter referred to as “1”)Īnd have made that learning part much easier. Thankfully, Chris Park and Arcen Games have learned a thing This level of asymmetry in power is very seldom seen and provides quite the challenge, once you figure out how you’re meant to fight back. You and your upstart rebellion will face incredible odds as you decided to fight back against the AI. In both games, a malevolent AI has conquered the galaxy and now controls every system but one: yours. Feel free to go to our discord ( ) and post here: if you’re interested in being a part of either the early alpha or a later phase.Easily one of the most unique aspects of AI War 1 & 2 is the concept. We’ll roll back around to regular tester additions as soon as we can. 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The following cards have been adjusted to be less powerful: We’ll keep an eye on how these changes land and we hope you’ll join us for the World Championships on December 16th and 17th! We have another balance patch window lined up for shortly after Worlds where we’ll be able to make more changes-including maybe some more adventurous buffs. Excavate as a whole got a little love with buffs to a Treasure at each rarity, the Neutral Burrow Buster, and a couple low-performance class Excavate cards. We’re also taking this opportunity to buff some underperforming archetypes, especially with new cards. That lets us take a high confidence, step-wise approach with this patch, instead of making risky, drastic changes.Įnrage Warrior was the biggest standout we wanted to adjust down, and we wanted to make Sif Mage a bit more attackable. Patch 28.2.1 is a data-only patch launching today with the following updates.ĭev Comment: This is our balance patch for Worlds! 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Once your devices are linked, your Android device will prompt you for several device permissions.Use this screen to scan the QR code that's displayed on your PC. On your Android device, the companion app should be open to a screen with a camera on it. A QR code will appear on your PC screen.On your Android device, you'll be prompted to enter the code displayed on your PC. Note: If you'd like to pair your device without using a QR code, select the Pair manually button on your PC instead. Then select the Pair with QR code button. Once you've signed in, go back to your PC and select the I have the Link to Windows app installed on my phone check box.The app will then open to a screen that displays a QR code for you to scan-we'll come back to that. Sign in to the companion app with the same Microsoft account that you're signed in to on your PC.To do this, open a web browser on your Android device and then enter the link that's displayed on your PC (aka.ms/yourpc). 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Phone Link connects to your Android phone via Wi-Fi, mobile data network or instant hotspot 8 9. When you open the app, you'll be guided through a few extra steps you'll need to take to finish setting things up. You'll find Phone Link pre-installed if you have the Windows 10 October 2019 Update or later. An Android device running Android 7.0 (Nougat) or above.Any Windows version after the May 2019 Update will have the app pre-installed. If you're currently running the May 2019 Update, you will need to install the Phone Link app from the Microsoft Store.Phone Link requires the following to work:.Read and reply to messages with ease, view recent photos from your Android device, use your favourite mobile apps 6, make and receive calls, and manage your Android device’s notifications right on your PC. This link between your device and PC gives you instant access to everything you love. In the Microsoft Store, you’ll see Phone Link. 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